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Adenosyl methionine or SAM-e is a substance produced by the liver. It was first discovered by G. L. Cantoni in 1952. SAM-e has many functions. Firstly, it promotes cellular growth and repair. Secondly, it helps in the synthesis of several hormones and neurotransmitters. Lastly, studies have shown that SAM-e may help prevent cognitive impairment caused by oxidative damage in brain cells.